Table 2.
Regions showing decreased positive AD-related RSFCs in insular subregions.
| ROIs | Brain regions | Cluster voxels | MNI Coordinates (mm) | Maximum Z | ||
|---|---|---|---|---|---|---|
| x | Y | z | ||||
| L. dAI | R.IFG | 140 | 45 | 15 | 6 | -5.52 |
| L.Thalamus | 41 | 0 | -15 | 6 | -4.38 | |
| R.MCC | 35 | 9 | 21 | 36 | -3.90 | |
| R. dAI | R.Insula | 73 | 33 | 15 | 12 | -4.39 |
| L.MTG | 64 | -48 | -63 | 3 | -4.79 | |
| L.Insula | 39 | -42 | 3 | 3 | -4.14 | |
| R.MFG | 31 | 39 | 39 | 12 | -4.61 | |
| L.IFG | 31 | -42 | 30 | 9 | -3.91 | |
| L.MCC | 33 | -9 | 12 | 36 | -4.19 | |
| R. PI | R.IOG | 216 | -36 | -75 | -3 | -4.87 |
| L.STG | 57 | -54 | -30 | 15 | -5.57 | |
Between groups differences were determined by two-sample t-tests [p < 0.05, false discovery rate (FDR) corrected, two tailed]. IFG, inferior frontal gyrus; MCC, middle cingulate cortex; MTG, middle temporal gyrus; MFG, middle frontal gyrus; IOG, inferior occipital gyrus; STG, superior temporal gyrus; L, left; R right; RSFC, resting-state functional connectivity; AD, Alzheimer’s disease; MNI, Montreal Neurological Institute; dAI, dorsal anterior insula; PI, posterior insula.