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. 2018 Apr 11;9:713. doi: 10.3389/fmicb.2018.00713

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Copyright © 2018 Velásquez, Amako, Harold, Toptan, Chang and Shuda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Establishment of the Merkel cell polyomavirus (MCV)-positive CVG-1 cell line from metastatic Merkel cell carcinomas (MCC). (A) Hematoxylin/eosin (H&E) staining (top) and MCV large T (LT) immunohistochemistry (bottom) of the metastatic MCC tissue that the CVG-1 cell line was established from. MCV LT-positive MCC tumor cells (brown nuclei) demonstrate significant variation in cell size (inset). (B) Morphology of the CVG-1 cell line under phase contrast microscopy. CVG-1 exhibits cell size variation and a small round appearance resembling lymphoid cell lines, as opposed to other MCV-positive MCC cell lines, such as MKL-1, which usually grow in loosely aggregated clusters.