Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Apr 6;14:786–795. doi: 10.3762/bjoc.14.66

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018, Yu et al.

This is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)

PMC Copyright notice

Scheme 6 — Synthesis of axitinib by mechanochemical Heck–Migita coupling. Reagents and conditions: (i) NBS, NaOH, silica gel (4.0 g), 173 stainless-steel balls (d_MB = 6 mm, Ф_MB = 0.245), 200 rpm, 30 min; (ii) CH₃SO₃H, dihydropyran, silica gel (4.0 g), 173 stainless-steel balls (d_MB = 6 mm, Ф_MB = 0.245), 200 rpm, 45 min; (iii) compound 2n, Pd(OAc)₂, PPh₃, TBAB, TEA, NaBr (10.0 g), 207 stainless-steel balls (d_MB = 6 mm, Ф_MB = 0.293), 700 rpm, 90 min; (iv) compound 6, Pd₂(dba)₃, Xantphos, Cs₂CO₃, silica gel (4.0 g), 207 stainless-steel balls (d_MB = 6 mm, Ф_MB = 0.293), 750 rpm, 50 min; (v) p-TsOH, silica gel (4.0 g), 207 stainless-steel balls (d_MB = 6 mm, Ф_MB = 0.293), 500 rpm, 45 min.