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. 2018 Apr 4;14:756–771. doi: 10.3762/bjoc.14.64

Figure 2.

Figure 2

Degradation of the GnRH-III bioconjugates by rat liver lysosomal homogenate. A) Cleavage sites produced by the proteolysis of bioconjugates in the presence of rat liver lysosomal homogenate (full-line arrows). B) Structure of the smallest Dau-containing metabolite and its corresponding mass spectra (analysis of K1 after 24 h incubation at the retention time 16.2–16.6 min of the LC–MS chromatogram). C) LC–MS chromatogram of the GnRH-III bioconjugates after 24 h of incubation with rat liver lysosomal homogenate at 37 °C (asterisk labeling peak of the smallest Dau-containing metabolite H-K(Dau=Aoa)-OH).