FIGURE 7:

Model for nuclear envelope repair in C. elegans. Nuclear envelope ruptures at weakened sites of the nuclear lamina are cleared of nuclear pore complexes (NPCs; orange). LEM-2 (magenta) and ESCRT-III (dark blue) are recruited to ruptured membranes. Dynein forces pull ruptured nuclear membranes apart, causing prolonged nucleo–cytoplasmic mixing. Lamin stabilizes NE rupture sites to allow narrowing of opposing membranes for fission by ESCRT-III machinery, which restricts further nucleo–cytoplasmic mixing. Full recovery of repaired nuclei reestablishes the nuclear permeability barrier and allows reinsertion of NPCs.