TABLE 2.
Case-control analysis of genetic variants associated with MMF-related leukopenia adjusting for trimethoprim/sulfamethoxazole, valganciclovir, and induction status
| Function | Gene | Change | RS# | Major allele | All
|
Depleting
|
Non-depleting
|
|||
|---|---|---|---|---|---|---|---|---|---|---|
| P value | OR CI | P value | OR CI | P value | OR CI | |||||
| Metabolism | UGT1A9 | −2152C>T | rs17868320 | C | .235 | 0.38 (0.08–1.88) | .991 | 1.000 | 1.00 (0.14–7.10) | |
| UGT1A9 | −440C>T | rs2741045 | C | .171 | 1.85 (0.77–4.45) | .980 | .780 | 1.17 (0.39–3.54) | ||
| UGT1A9 | −665C>T | rs10176426 | C | .618 | 0.67 (0.14–3.21) | .989 | .976 | |||
| UGT1A9 | −275T>A | rs6714486 | T | .225 | 0.39 (0.09–1.79) | .991 | .649 | 0.65 (0.10–4.09) | ||
| UGT1A8 | *2 | rs1042597 | C | .614 | 0.80 (0.34–1.90) | 1.000 | 1.00 (0.20–4.95) | 1.000 | 1.00 (0.28–3.51) | |
| UGT1A8 | *3 | rs17863762 | G | .678 | 0.68 (0.11–4.20) | .991 | .571 | 0.50 (0.05–5.51) | ||
| UGT2B7 | −900A>G | rs7438135 | A | .071 | 0.45 (0.19–1.07) | .303 | 2.85 (0.39–20.85) | .038* | 0.19 (0.04–0.91) | |
| UGT1A7 | −57T>G | rs7586110 | T | .398 | 1.47 (0.60–3.59) | .215 | 4.00 (0.45–35.79) | 1.000 | 1.00 (0.25–4.00) | |
| CYP3A5 | *3 | rs776746 | G | .319 | 1.72 (0.59–4.98) | 1.000 | 1.00 (0.06–15.99) | .101 | 5.78 (0.71–47.06) | |
| CYP3A4 | *22 | rs35599367 | C | .201 | 0.20 (0.02–2.33) | .984 | ||||
| CYP2C8 | rs11572076 | G | .296 | 0.26 (0.02–3.27) | .994 | .978 | ||||
|
| ||||||||||
| Transport | MDR1/ABCB1 | 1236C>T | rs1128503 | C | .411 | 0.77 (0.40–1.45) | .197 | 0.29 (0.05–1.89) | .654 | 0.82 (0.33–1.99) |
| MDR1/ABCB1 | 3435C>T | rs1045642 | T | .360 | 1.36 (0.70–2.62) | .215 | 4.00 (0.45–35.79) | 1.000 | 1.00 (0.46–2.17) | |
| MDR1/ABCB1 | 2677G>T/A | rs2032582 | G | .366 | 1.40 (0.67–2.92) | .491 | 0.59 (0.13–2.65) | .178 | 2.08 (0.72–6.05) | |
| MRP2/ABCC2 | −24C>T | rs717620 | C | .997 | 1.00 (0.37–2.73) | .986 | .703 | 0.74 (0.16–3.50) | ||
| MRP2/ABCC2 | rs12762549 | C | .601 | 1.21 (0.59–2.49) | .378 | 1.78 (0.49–6.40) | .780 | 0.85 (0.28–2.58) | ||
| SLCO1B1 | Val 174 Ala | rs4149056 | T | .568 | 1.32 (0.51–3.46) | .571 | 2.00 (0.18–22.06) | .752 | 1.22 (0.35–4.25) | |
| SLCO1B1 | Pro 155 Thr | rs11045819 | C | .655 | 1.22 (0.51–2.96) | .740 | 0.80 (0.21–3.01) | .372 | 1.75 (0.51–5.98) | |
| SLCO1B3 | 334T>G | rs4149117 | G | .478 | 0.75 (0.34–1.66) | .984 | .773 | 1.18 (0.38–3.68) | ||
| SLCO1B3 | rs11045585 | A | .737 | 1.17 (0.48–2.86) | .980 | .761 | 1.21 (0.36–4.00) | |||
| BCRP/ABCG2 | 421C>A | rs2231142 | C | .612 | 1.30 (0.47–3.63) | .571 | 0.50 (0.05–5.51) | .259 | 3.17 (0.43–23.44) | |
|
| ||||||||||
| Target | IMPDH1 | rs2278293 | G | .590 | 1.24 (0.57–2.70) | .740 | 0.80 (0.21–3.01) | .596 | 1.34 (0.46–3.93) | |
| IMPDH1 | rs2278294 | G | .512 | 0.77 (0.35–1.69) | .740 | 1.25 (0.33–4.71) | .198 | 0.39 (0.10–1.63) | ||
| IMPDH1 | rs2228075 | G | .648 | 1.23 (0.50–3.05) | .708 | 0.75 (0.16–3.43) | .761 | 1.21 (0.36–4.06) | ||
| IMPDH2 | rs4974081 | T | .639 | 1.23 (0.52–2.87) | .657 | 1.50 (0.25–8.98) | .596 | 0.75 (0.25–2.20) | ||
| IMPDH2 | 3757T>C | rs11706052 | A | .297 | 0.53 (0.16–1.75) | .979 | .173 | 0.16 (0.01–2.21) | ||
*
p value < 0.05