TABLE 3.
Genetic association with time to leukopenia
| Marker | Major allele | All | Depleting | Non-depleting | |||
|---|---|---|---|---|---|---|---|
| Beta ± SE | P value | Beta ± SE | P value | Beta ± SE | P value | ||
| #01: MDR1-3435 C-T_rs1045642 | T | 0.02 ± 0.10 | .8459 | −0.002 ± 0.20 | .9932 | 0.03 ± 0.12 | .8022 |
| #02: ABCB1_rs1128503_C___7586662 | C | −0.001 ± 0.0 | .9899 | 0.09 ± 0.20 | .6474 | −0.06 ± 0.12 | .6400 |
| #03: SLCO1B3_rs4149117_C__256391 | G | 0.03 ± 0.12 | .7933 | 0.38 ± 0.24 | .1221 | −0.15 ± 0.13 | .2544 |
| #04: SLCO1B1_rs4149056_C__306339 | T | −0.10 ± 0.17 | .5580 | 0.25 ± 0.34 | .4592 | −0.28 ± 0.19 | .1487 |
| #06: MRP2-24_rs717620 | C | −0.13 ± 0.18 | .4815 | 0.38 ± 0.36 | .2984 | −0.37 ± 0.19 | .0560 |
| #07: IMPDH2_rs11706052_C___18429 | A | −0.21 ± 0.18 | .2458 | −0.50 ± 0.28 | .0866 | 0.03 ± 0.24 | .9092 |
| #08: IMPDH1_rs2228075_C__2694004 | G | −0.35 ± 0.12 | .0046* | −0.46 ± 0.23 | .0587 | −0.33 ± 0.15 | .0343 |
| #09: IMPDH1_rs2278293_C__1596518 | G | −0.23 ± 0.11 | .0458* | −0.40 ± 0.21 | .0705 | −0.14 ± 0.14 | .3040 |
| #10: SLCO1B1-155_rs11045819_SLCO | C | 0.19 ± 0.17 | .2551 | 0.07 ± 0.27 | .8077 | 0.43 ± 0.23 | .0743 |
| #11/#12: ABCB1_RS2032582 | G | 0.05 ± 0.10 | .6370 | 0.26 ± 0.19 | .1921 | −0.06 ± 0.12 | .6301 |
| #13: ABCG2_rs2231142_C__15854163 | C | −0.25 ± 0.19 | .1799 | 0.02 ± 0.35 | .9647 | −0.50 ± 0.22 | .0248 |
| #14: UGT1A8*3_rs17863762 | G | −0.19 ± 0.34 | .5825 | – | – | −0.17 ± 0.32 | .5987 |
| #15: UGT1A8*2_rs1042597_C__11742 | C | −0.18 ± 0.15 | .2370 | −0.28 ± 0.28 | .3270 | −0.13 ± 0.19 | .4874 |
| #17: UGT1A9-2152_rs17868320 | C | −0.26 ± 0.22 | .2416 | −0.33 ± 0.34 | .3400 | −0.17 ± 0.32 | .5987 |
| #18: UGT1A9-275_rs6714486 | T | −0.15 ± 0.19 | .4149 | −0.33 ± 0.34 | .3400 | −0.01 ± 0.26 | .9823 |
| #20: UGT1A9-440_rs2741045 | C | 0.08 ± 0.12 | .5034 | −0.41 ± 0.32 | .2216 | 0.23 ± 0.12 | .0664 |
| #21: UGT1A9_rs10176426_C__303416 | C | 0.18 ± 0.21 | .4015 | 0.11 ± 0.37 | .7694 | 0.27 ± 0.28 | .3455 |
| #22: UGT2B7-900_rs7438135 | A | −0.09 ± 0.11 | .4404 | −0.31 ± 0.22 | .1880 | 0.03 ± 0.13 | .7752 |
| #23: UGT1A7_rs7586110_C____28726 | T | 0.02 ± 0.11 | .8603 | −0.45 ± 0.24 | .0807 | 0.23 ± 0.12 | .0648 |
| #24: ABCC2_rs12762549_C__1121491 | C | −0.02 ± 0.12 | .8493 | 0.34 ± 0.22 | .1406 | −0.21 ± 0.13 | .1147 |
| #25: SLCO1B3_rs11045585_C__31106 | A | 0.20 ± 0.14 | .1552 | 0.38 ± 0.30 | .2286 | 0.11 ± 0.15 | .4782 |
| #27: CYP3A5*3_rs776746 | G | −0.17 ± 0.14 | .2439 | 0.03 ± 0.25 | .8942 | −0.34 ± 0.17 | .0553 |
| #36: CYP3A4*22_rs35599367_C__590134 | C | −0.53 ± 0.29 | .0718 | −0.43 ± 0.40 | .2937 | −0.86 ± 0.50 | .0977 |
| #49: IMPDH1_rs2278294_C___283083 | G | −0.23 ± 0.11 | .0382* | −0.42 ± 0.21 | .0592 | −0.13 ± 0.12 | .3241 |
| #50: IMPDH2_rs4974081_C__2576349 | T | −0.02 ± 0.13 | .8901 | 0.13 ± 0.21 | .5303 | −0.14 ± 0.16 | .3809 |
| #56: CYP2C8_rs11572076_C__3165811 | G | −0.18 ± 0.28 | .5273 | 0.07 ± 0.51 | .8907 | −0.35 ± 0.33 | .2898 |
Beta values are for natural log transformation of days.
*
p value < 0.05