Figure 2.
Simulated steady-state AUC0–24, with proposed adjusted weight-band dosing to compensate for low RMP bioavailability in patients with weight < 55 kg. Panel A = dosed as a fully compliant four-drug fixed-dose combination; Panel B = assuming a 20% decrease in bioavailability across all weight bands, with our proposed adjusted weight-band dosing plus an additional single 150 mg dose of RMP with 100% bioavailability dosed in all weight bands. Weight bands: 30–37 kg, 3 tablets; 38–54 kg, 4 tablets; 55–70 kg, 4 tablets; >70 kg, 5 tablets. Median = box midline; interquartile range = upper and lower bounds of boxes; 95% range = upper and lower bounds of whiskers. AUC0–24 = area under the RMP concentration-time curve to 24 h; RMP = rifampicin.