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. 2000 Jul;123(3):917–928. doi: 10.1104/pp.123.3.917

Figure 3.

Figure 3

Sequence analysis of the Cs1-MMP cDNA. A, Nucleotide sequence of the Cs1-MMP cDNA. The deduced amino acid sequence is shown below the coding sequence and the asterisk indicates the termination codon. The white arrow denotes the 5′ end of the partial cDNA. The dotted line indicates poly(A) stretches intervening within positions 403 through 434 and responsible for oligo(dT) priming during reverse transcription leading to the synthesis of the partial cDNA. The black arrow denotes the putative signal peptide cleavage site. The single-underlined sequence represents the propeptide motif characteristic of the propeptide domain. Double-underlined sequences indicate the zinc-binding consensus sequence and the Met-turn-like motif characteristics of the catalytic domain. Cs1-MMP polyadenylation sites at the 3′ end of the sequence, identified by RACE-PCR, are indicated with a dot. The EMBL data library accession number is AJ133371. B, Schematic representation of the predicted Cs1-MMP protein showing the pre-pro-enzyme, which displays all the hallmark motifs of MMPs, propeptide, zinc binding, and Met-turn motifs.