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. Author manuscript; available in PMC: 2018 May 19.
Published in final edited form as: ACS Chem Biol. 2017 Apr 10;12(5):1170–1182. doi: 10.1021/acschembio.7b00237

Figure 2. Electroporation induces and targets oxidized lipids at the cell membrane.

Figure 2

Externally applied electric pulse as well as environmental oxidative stress can generate a variety of oxidized lipids, including aldehyde-containing species. Molecular dynamic simulations have suggested that additional electric pulsing leads these oxidized species to preferentially form pores within the lipid bilayer. Electroporation may therefore involve of a mechanism where oxidized lipids are both generated and directly utilized for permeation.