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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Neurotoxicology. 2017 Nov 26;65:280–288. doi: 10.1016/j.neuro.2017.11.008

Fig. 1.

Fig. 1

Effects of E2 and TX on Mn-induced decrease in locomotor activity in mice. (A) Experimental paradigm. C57BL/6 ovariectomized female mice were implanted with E2 or TX pellets in the back of the neck of mice prior to striatal administration of Mn in the right side of mouse brain as described in the Methods section. (B) Locomotor activity was assessed in an open-field on 21 days after treatment of E2, TX, and Mn. Total distances traveled were measured in each group of mice. ##, p<0.01; *, p<0.05 (two-way ANOVA followed by Tukey’s post hoc test; n = 8).