Table 2.
Quartile distribution of TNF-α level to assess the risk of POAG
| TNF-α (pg/mL) by quartilesa | Cases (n = 51), n (%) | Controls (n = 88), n (%) | Odds ratio | 95% confidence interval | p-value |
|---|---|---|---|---|---|
| 0 | 18 (35.3) | 51 (57.9) | Reference | – | – |
| 0.1–2.3 | 13 (25.5) | 21 (23.8) | 1.75 | 0.73–4.21 | 0.206 |
| >2.3 | 20 (39.2) | 16 (18.1) | 3.54 | 1.51–8.27 | 0.0028 |
Notes:
a
First quartile: <25th percentile; interquartile: 25th–75th percentile; third quartile: >75th percentile. Overall dose–response trend was significant (χ2 = 6.12, df = 2; p = 0.047).
Abbreviations: POAG, primary open-angle glaucoma; TNF-α, tumor necrosis factor alpha.