Table 1:
Representative xenobiotic responsive genes differentially expressed in liver and brain in response to PCB126 exposure
| Gene name | Gene symbol | Liver |
Brain |
||
|---|---|---|---|---|---|
| logFC | FDR | logFC | FDR | ||
| AHR repressor a | ahrra | 10.677 | 7.21E–46 | 3.850 | 1.12E–02 |
| AHR repressor b | ahrrb | 7.500 | 4.89E–04 | 2.669 | 3.68E–02 |
| AHR interacting protein | aip | 0.553 | 3.90E–02 | ||
| AHR nuclear translocator-like 1a | arntl1a | –0.694 | 2.71E–02 | ||
| AHR nuclear translocator-like 1b | arntl1b | –0.792 | 3.38E–02 | ||
| AHR nuclear translocator-like 2 | arntl2 | –1.758 | 2.75E–03 | –1.033 | 2.53E–02 |
| Cytochrome P4501a | cyp1a | 5.420 | 3.40E–20 | 8.571 | 8.60E–85 |
| Cytochrome P4501b1 | cyp1b1 | 7.750 | 1.35E–16 | 1.834 | 3.11E–03 |
| Cytochrome P450, family 1, subfamily C, polypeptide 1 | cyp1c1 | 5.433 | 6.30E–17 | 4.745 | 7.26E–06 |
| Cytochrome P450, family 1, subfamily C, polypeptide 2 | cyp1c2 | 2.887 | 2.44E–06 | 3.058 | 6.81E–03 |
| Cytochrome P450, family 2, subfamily AA, polypeptide 12 | cyp2aa12 | 1.443 | 3.88E–02 | ||
| Cytochrome P450, family 2, subfamily AA, polypeptide 4 | cyp2aa4 | 2.662 | 2.04E–02 | ||
| Cytochrome P450, family 2, subfamily K, polypeptide 22 | cyp2k22 | –5.654 | 2.50E–02 | ||
| Cytochrome P450, family 2, subfamily K, polypeptide 31 | cyp2k31 | –5.169 | 3.10E–07 | ||
| Cytochrome P450, family 2, subfamily K, polypeptide 6 | cyp2k6 | 8.607 | 1.52E–02 | ||
| Cytochrome P450, family 2, subfamily X, polypeptide 10.2 | cyp2x10.2 | 3.495 | 2.32E–10 | ||
| Cytochrome P450, family 2, subfamily AD, polypeptide 3 | cyp2ad3 | 1.055 | 1.79E–02 | ||
| Cytochrome P450, family 2, subfamily P, polypeptide 6 | cyp2p6 | 1.005 | 6.51E–03 | ||
| Cytochrome P450, family 2, subfamily V, polypeptide 1 | cyp2v1 | 1.348 | 9.56E–03 | ||
| Cytochrome P450, family 26, subfamily b, polypeptide 1 | cyp26b1 | 0.985 | 9.56E–03 | ||
| Glutathione S-transferase theta 1b | gstt1b | 1.349 | 4.30E–02 | ||
| Microsomal glutathione S-transferase 3b | mgst3b | 2.050 | 7.38E–04 | 0.762 | 1.18E–02 |
| Glutathione S-transferase theta 1a | gstt1a | 3.983 | 3.73E–02 | ||
| Glutathione S-transferase mu, tandem duplicate 1 | gstm.1 | 0.619 | 3.15E–02 | ||
| Glutathione S-transferase rho | gstr | 0.768 | 3.90E–02 | ||
| Glutathione S-transferase pi 1 | gstp1 | 0.883 | 3.43E–02 | ||
| Glutamate-cysteine ligase, modifier subunit | gclm | 1.779 | 1.52E–03 | ||
| Glutathione reductase | gsr | 1.498 | 3.79E–03 | ||
| Glucose-6-phosphate dehydrogenase | g6pd | 1.610 | 1.96E–02 | ||
| NAD(P)H dehydrogenase, quinone 1 | nqo1 | 1.951 | 3.42E–02 | ||
| Kelch-like ECH-associated protein 1b | keap1b | 1.308 | 4.11E–02 | ||
| UDP glucuronosyltransferase 1 family, polypeptide B5 | ugt1b5 | 1.633 | 2.20E–02 | ||
| UDP glucuronosyltransferase 1 family, polypeptide B1 | ugt1b1 | 1.667 | 6.72E–03 | ||
| UDP glucuronosyltransferase 1 family, polypeptide B2 | ugt1b2 | –2.217 | 3.98E–02 | ||
| UDP glucuronosyltransferase 1 family, polypeptide B7 | ugt1b7 | –2.779 | 8.30E–05 | ||
| UDP glucuronosyltransferase 5 family, polypeptide C2 | ugt5c2 | –2.099 | 1.03E–02 | ||
| UDP glucuronosyltransferase 1 family, polypeptide A6 | ugt1a6 | 4.251 | 3.13E–02 | ||
| Phosphogluconate dehydrogenase | pgd | 1.856 | 4.99E–03 | ||