Figure 5. . Importance of the window blood sampling.
(A) Window blood sampling with tf = 3 h and (B) window blood sampling with tf = 10 h for the same entity. In the first case (A), the window is too short and the elimination phase is not described alone. The slope (1.59 h-1) could be considered as the rate of elimination whereas it is the consequence of distribution and elimination process. If an optimal design is obtained (including later points ‘×’, case [B]), the real elimination rate is close to 0.1 h-1.
tf: Time of the last sample obtained during assay.