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Respiratory chain deficiency in sedentary PolgA+/+ mice (A), sedentary PolgAmut/mut mice (B) and exercised PolgAmut/mut mice (C) colon, showing a transverse section through the crypts. Scale bars: 100 μm. Colonic crypts stained brown are positive for COX activity (blue arrow), those stained blue are deficient for COX activity (green arrow), and crypts stained purple/brown display intermediate COX deficiency (red arrow).
