Table 1.

IPA® Gene Set Enrichment Analysis of Genes Modulated by VPA

Genes	Top 5 functions (p value)	Top 5 Regulators (p value)	Top 5 canonical pathways (p value)
Up-regulated	1. Differentiation of neurons (6.03E-45) 2. Quantity of cells (6.63E-42) 3. Circadian rhythm (4.84E-32) 4. CNS morphology (1.01E-31) 5. Neurogenesis (4.42E-30)	1. VPA (3.94E-43) 2. HTT (1.17E-32) 3. NEUROD1 (1.66E-32) 4. ASCL1 (8.04E-30) 5. BDNF (1.01E-19)	1. Corticotrophin releasing hormone signaling (1.17E-13) 2. Circadian rhythm signaling (2.81E-13) 3. Transcriptional regulatory networks in embryonic stem cells (3.15E-14) 4. Glucocorticoid receptor signaling (1.19E-12) 5. Nitric oxide signaling (2.77E-10)
Down-regulated	1. Apoptosis (5.12E-28) 2. Glial cell proliferation (6.07E-26) 3. Migration of cells (1.1E-24) 4. Chemotaxis of endothelial cells (1.15E-22) 5. Cell movement of endothelial cells (1.06E-18)	1. VPA (1.32E-23) 2. OLIGO2 (9.99E-21) 3. FGF7 (1.02E-15) 4. PROX1 (6.09E-11) 5. PRXX1 (2.31E-09)	1. Apoptosis signaling (3.44E-22) 2. Cellular movement (1.21E-20) 3. LXR/RXR activation (3.93E-16) 4. RHOA signaling (2.65E-10) 5. Caveolar-mediated endocytosis signaling (7.99E-09)

IPA = Ingenuity Pathway Analysis; VPA = valproic acid.