Table 3.
Number of studies | OR (95% CI) Fixed effects | OR (95% CI) Random effects | Ri* | Q test P values | |
All studies | 13 | 1.71 (1.63 to 1.78) | 1.79 (1.39 to 2.32) | 0.96 | 0.0001 |
Case-control studies | 5 | 1.27 (1.10 to 1.47) | 2.48 (1.30 to 4.76) | 0.93 | 0.0001 |
Cross-sectional studies | 7 | 2.02 (1.91 to 2.12) | 1.76 (1.32 to 2.36) | 0.95 | 0.0001 |
Direct calculations | 12 | 1.91 (1.82 to 2.01) | 1.90 (1.45 to 2.49) | 0.95 | 0.0001 |
Quality score ≥3 | 8 | 1.20 (1.11 to 1.29) | 1.41 (1.14 to 1.74) | 0.81 | 0.001 |
Quality score <3 | 5 | 2.05 (1.95 to 2.16) | 2.33 (1.60 to 3.41) | 0.96 | 0.0001 |
Full adjustment | 6 | 1.17 (1.08 to 1.26) | 1.23 (1.03 to 1.48) | 0.72 | 0.03 |
Incomplete adjustment | 7 | 2.05 (1.95 to 2.16) | 2.25 (1.66 to 3.05) | 0.95 | 0.0001 |
Validated exposure | 7 | 1.18 (1.09 to 1.27) | 1.32 (1.06 to 1.64) | 0.81 | 0.003 |
Non validated exposure | 6 | 2.06 (1.95 to 2.17) | 2.25 (1.66 to 3.06) | 0.95 | 0.0004 |
Validated diagnosis | 7 | 1.95 (1.85 to 2.06) | 1.98 (1.31 to 3.00) | 0.98 | 0.0001 |
Non validated diagnosis | 6 | 1.26 (1.16 to 1.36) | 1.58 (1.22 to 2.05) | 0.86 | 0.001 |
High response rate | 4 | 1.23 (1.06 to 1.42) | 1.84 (1.07 to 3.17) | 0.91 | 0.001 |
Low response rate | 9 | 1.76 (1.68 to 1.84) | 1.80 (1.32 to 2.47) | 0.97 | 0.0001 |
Defined target population | 8 | 1.23 (1.15 to 1.32) | 1.45 (1.21 to 1.75) | 0.78 | 0.001 |
Undefined target population | 5 | 2.09 (1.98 to 2.21) | 2.49 (1.36 to 4.58) | 0.99 | 0.0001 |
US studies | 9 | 1.92 (1.83 to 2.02) | 1.91 (1.41 to 2.59) | 0.96 | 0.0001 |
Rest of the world | 4 | 1.19 (1.09 to 1.30) | 1.58 (0.95 to 2.63) | 0.96 | 0.001 |
*Proportion of total variance due to between-study variance.