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. 2018 Apr 17;8(4):e019635. doi: 10.1136/bmjopen-2017-019635

Table 3.

Subgroup results of RFS and heterogeneity test

Variables Analysis number HR (95% CI) Heterogeneity test
Q P I2 (%)
Total RFS 7 1.331 (0.980 to 1.809) 9.48 0.148 36.7
Region
 Asian 2 0.892 (0.454 to 1.752) 0.32 0.570 0.0
 Caucasian 5 1.441 (1.014 to 2.047) 7.52 0.111 46.8
Sample size
 >100 4 1.466 (0.986 to 2.181) 7.44 0.059 59.7
 ≤100 3 0.959 (0.534 to 1.725) 0.51 0.777 0.0
Follow-up (month)
 ≥60 3 1.036 (0.758 to 1.415) 0.79 0.674 0.0
 <60 4 1.853 (1.316 to 2.607) 2.62 0.453 0.0
Stage
 All NMIBC 3 1.575 (0.915 to 2.711) 4.44 0.109 54.9
 Others 4 1.153 (0.821 to 1.620) 3.21 0.360 6.6
Cut-off
 15% 2 1.625 (0.963 to 2.743) 0.31 0.575 0.0
 Others 5 1.252 (0.839 to 1.869) 8.56 0.073 53.3
Publication year
 ≥2012 4 1.164 (0.874 to 1.550) 3.20 0.362 6.3
 <2012 3 1.774 (1.046 to 3.008) 2.57 0.277 22.1
Patient age (year)
 ≥70 3 1.352 (0.955 to 1.913) 1.16 0.559 0.0
 <70 4 1.256 (0.717 to 2.198) 8.32 0.040 63.9

NMIBC, non-muscle invasive bladder cancer; RFS, recurrence-free survival.