Table 1.

Most frequent side effects of all approved TKI

	Imatinib	Nilotinib	Dasatinib	Bosutinib	Ponatinib
Hematologic	Neutropenia		Neutropenia, thrombocytopenia
Lab values	Phosphate	Lipase, ALT, AST, blood glucose	Changes in coagulation parameters	ALT, AST, Lipase	Lipase, blood glucose, cholesterol, triglyceride
Non-lab AEs	Muscle cramps, edema	Rash, PAOD, other vascular events	Pleural effusion, Pulmonal hypertension	Nausea, vomiting, diarrhea	Rash, PAOD, arterial and venous events, arterial hypertension

Abbreviation: AEs, adverse events; ALT, alanine transaminase; AST, aspartate transaminase; PAOD, peripheral arterial vascular occlusive disease; TKI, tyrosine kinase inhibitors.