Fig. 5.

Human outer retinal morphometry with visible light OCT. (A-B) A single B-scan with a zoom of the outer retina shows a transition from the fovea to periphery. (C) Zoom of the outer retina after flattening. (D) Average axial signal intensity profile between the white lines in A. (IS / OS: Inner Segment / Outer Segment Junction, COST: Cone Outer Segment Tips, ROST: Rod Outer Segment Tips, RPE: Retinal Pigment Epithelium, BM: Bruch’s Membrane). In addition to delineation of the layers on a linear scale, two peaks are evident in the IS / OS band at 9° eccentricity. (E) Thickness measurements of the BM, IS / OS junction, COST, and RPE bands (assuming a refractive index of 1.4). (F) The signal from the choriocapillaris (CC) is lowest in the fovea (0° eccentricity), and increases with eccentricity. (G) The optical density difference (ODD) of the RPE (defined as the natural logarithm of the ratio of the BM to distal OST signal in the λ₂ = 610 nm sub-band divided by the same ratio in the λ₁ = 560 nm sub-band) shows a peak near the fovea (shaded areas show standard deviations across 5 scans) in agreement with expected RPE melanin distribution [33]. Subjects 1 and 2 are males of age 36 and 26 respectively.