Table 1.

Transcriptome Analysis of Extracellular Matrix-Related Genes in Fuchs Endothelial Corneal Dystrophy Cultured Cells

Gene name	Mean linear value ± SD	Fold change relative to healthy controls	p
Collagen genes
COL1A1	823 ± 676	1.0	0.966
COL1A2	13 955 ± 5 286	−1.2	0.476
COL3A1	260 ± 130	−1.4	0.418
COL4A1	246 ± 374	−1.3	0.829
COL4A2	2 990 ± 3 582	−1.2	0.808
COL4A3BP	705 ± 128	1.1	0.236
COL4A4	298 ± 225	−2.3	0.329
COL4A5	1 630 ± 437	−1.1	0.591
COL4A6	2 043 ± 742	−1.2	0.311
COL5A1	361 ± 170	−1.3	0.471
COL5A2	5 303 ± 1 639	−1.2	0.451
COL6A1	7 333 ± 4 739	1.1	0.697
COL6A2	344 ± 524	2.2	0.426
COL7A1	526 ± 210	−1.4	0.132
COL8A1	11 144 ± 4 428	−1.7	0.052
COL8A2	823 ± 967	−2.6	0.146
COL9A3	2 178 ± 3 370	1.7	0.528
COL12A1	11 575 ± 6 420	−1.5	0.274
COL13A1	692 ± 362	1.4	0.376
COL16A1	1 580 ± 801	1.3	0.453
COL18A1	2 698 ± 1 685	1.2	0.648
COL21A1	98 ± 61	−2.0	0.206
COL24A1	119 ± 44	−1.5	0.306
Fibronectin genes
FN1	1 402 ± 1 998	1.5	0.648
FNDC3A	140 ± 65	−1.2	0.532
FNDC3B	439 ± 131	1.1	0.751
FNDC4	350 ± 86	1.8	0.022a
Laminin genes
LAMA3	559 ± 796	2.8	0.313
LAMA4	318 ± 79	1,1	0.588
LAMA5	314 ± 70	1.1	0.454
LAMB1	360 ± 35	1.0	0.771
LAMB2	5 957 ± 1 634	−1.2	0.370
LAMB3	249 ± 176	1.9	0.163
LAMC1	1 589 ± 731	−1.1	0.660
LAMC2	238 ± 145	−1.2	0.713
Other
CLU	6 668 ± 5 069	−1.3	0.508
CLUAP1	342 ± 80	−1.1	0.740
TGFBI	38 176 ± 5 415	1.3	0.105

Genes with linear values under 100 were excluded. Bold indicates a twofold down- or upregulation.

^aMeans significantly different (p < 0.05).

FNDC4, fibronectin type III domain containing 4; SD, standard deviation.