Table 2.
Transcriptome Analysis of Integrin-Related Genes in Fuchs Endothelial Corneal Dystrophy-Cultured Cells
| Gene name | Mean linear value ± SD | Fold change relative to healthy controls | p |
|---|---|---|---|
| Integrin genes | |||
| ITGA1 | 121 ± 51 | −1.4 | 0.161 |
| ITGA3 | 1 409 ± 439 | 1.0 | 0.843 |
| ITGA4 | 336 ± 224 | 1.6 | 0.262 |
| ITGA5 | 744 ± 488 | 1.8 | 0.147 |
| ITGA6 | 684 ± 317 | 1.7 | 0.102 |
| ITGA7 | 1 341 ± 1 476 | 1.1 | 0.881 |
| ITGA10 | 494 ± 372 | −2.4 | 0.273 |
| ITGA11 | 494 ± 476 | 1.2 | 0.771 |
| ITGAE | 428 ± 303 | 1.4 | 0.375 |
| ITGAV | 3 978 ± 833 | 1.0 | 0.907 |
| ITGB1 | 2 162 ± 1 117 | 1.1 | 0.863 |
| INTGB1BP1 | 224 ± 84 | 1.1 | 0.721 |
| ITGB3 | 196 ± 104 | 1.0 | 0.939 |
| ITGB3BP | 411 ± 361 | 1.6 | 0.399 |
| ITGB4 | 933 ± 676 | −1.6 | 0.239 |
| ITGB5 | 6 051 ± 1 667 | 1.4 | 0.049a |
| ITGB7 | 100 ± 47 | 1.2 | 0.441 |
| ITGBL1 | 3 292 ± 1 311 | −1.3 | 0.228 |
Genes with linear values under 100 were excluded. Bold indicates a twofold down- or upregulation.
a
Means significantly different (p < 0.05).