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. 2018 May 10;28(14):1286–1308. doi: 10.1089/ars.2017.7239

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© Lauren K. Wareham et al., 2018; Published by Mary Ann Liebert Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 1. — CO release from CORM-401 in bacterial growth medium. Assays were performed in Evans minimal medium (with glucose as sole carbon source) in the presence of excess dithionite at 37°C. (A) CO difference spectra showing the conversion of myoglobin (15 μM) to the carbonmonoxy-ferrous species in the presence of 3 μM CORM-401. (B) Time course of CO release from CORM-401 in medium at 37°C. Under these conditions, CORM-401 releases 2.5 mole equivalent of CO with a t_1/2 of 4.5 min. Data are means of three biological repeats ± SEMs. CORM, carbon monoxide-releasing molecule.