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. 2018 Apr 18;13(4):e0195658. doi: 10.1371/journal.pone.0195658

Table 5. Multinomial logistic regression- significant adjusted OR of characteristics and their association with age at natural menopause.

Characteristics Age at natural menopause (years)
≤40 OR(95% CI) 41–44 OR(95% CI) 45–49 OR(95% CI) ≥ 53 OR(95% CI)
Socio-demographic
Age (years)
≤50 4.38(2.88–6.68) 5.81(4.12–8.19) 5.86(4.59–7.50) 0.03(0.004–0.20)
51–55 0.20(0.14–0.27) 0.45(0.36–0.57) 0.66(0.58–0.75) 0.68(0.56–0.82)
56–60 0.36(0.28–0.48) 0.62(0.50–0.77) 0.78(0.70–0.88) 1.65(1.40–1.94)
61–65 0.52(0.40–0.69) 0.81(0.66–1.01) 0.87(0.77–0.98) 1.38(1.16–1.64)
>65 Ref. Ref. Ref. Ref.
Highest education
No formal school Ref. Ref. Ref. Ref.
Primary school 0.74(0.59–0.94) 0.81(0.69–0.96) 0.88(0.81–0.96) 1.20(1.07–1.35)
Middle school 0.98(0.56–1.70) 1.13(0.79–1.63) 0.96(0.77–1.18) 1.80(1.38–2.34)
High school or above 1.35(0.47–3.91) 1.59(0.81–3.14) 1.01(0.65–1.57) 2.26(1.34–3.83)
Lifestyle
Smoking status
Never Ref. Ref. Ref. Ref.
Occasional 0.52(0.22–1.20) 0.62(0.34–1.15) 0.89(0.67–1.17) 0.52(0.34–0.82)
current regular 1.46(0.89–2.41) 1.80(1.22–2.65) 1.21(0.94–1.56) 0.67(0.45–1.00)
Body mass index
Underweight 1.20(0.90–1.62) 1.55(1.25–1.93) 1.37(1.20–1.56) 0.75(0.61–0.92)
Normal weight Ref. Ref. Ref. Ref.
Overweight 0.85(0.69–1.05) 0.94(0.81–1.09) 0.93(0.85–1.00) 1.04(0.93–1.16)
Obesity 0.70(0.47–1.03) 0.84(0.64–1.09) 0.84(0.73–0.97) 1.08(0.90–1.30)
Physical activity
Low Ref. Ref. Ref. Ref.
Middle 1.10(0.89–1.36) 1.20(1.02–1.42) 0.95(0.87–1.04) 1.15(1.00–1.32)
High 1.12(0.87–1.45) 1.30(1.07–1.57) 0.89(0.81–0.99) 1.13(0.97–1.30)
Dietary
Meat
<1 day per week Ref. Ref. Ref. Ref.
1–3 days per week 0.93(0.72–1.20) 0.95(0.78–1.16) 1.10(0.98–1.23) 1.27(1.08–1.49)
≥4 days per week 0.85(0.65–1.13) 0.91(0.74–1.12) 0.99(0.88–1.12) 1.18(1.00–1.40)
Sea food
<1 day per week Ref. Ref. Ref. Ref.
1–3 days per week 0.94(0.78–1.14) 0.83(0.72–0.95) 0.84(0.78–0.91) 1.03(0.93–1.15)
≥4 days per week 0.95(0.51–1.79) 1.07(0.71–1.60) 0.92(0.73–1.16) 0.91(0.65–1.27)
Fresh eggs
<1 day per week Ref. Ref. Ref. Ref.
1–3 days per week 1.13(0.94–1.36) 0.87(0.76–1.00) 0.96(0.89–1.04) 0.94(0.85–1.05)
≥4 days per week 0.78(0.52–1.15) 0.74(0.56–0.96) 0.72(0.62–0.83) 0.80(0.66–0.98)
Fresh fruits
<1 day per week Ref. Ref. Ref. Ref.
1–3 days per week 0.60(0.49–0.73) 0.69(0.59–0.79) 0.90(0.83–0.97) 0.94(0.84–1.05)
≥4 days per week 0.54(0.40–0.73) 0.73(0.60–0.90) 0.90(0.81–1.01) 1.05(0.90–1.22)
Vitamins intake
Yes 0.54(0.35–0.84) 1.19(0.95–1.50) 0.94(0.82–1.07) 1.09(0.92–1.30)
No Ref. Ref. Ref. Ref.
Experienced severe food shortage
Yes 0.80(0.65–0.97) 0.82(0.71–0.95) 0.83(0.76–0.89) 1.09(0.97–1.22)
No Ref. Ref. Ref. Ref.
Reproductive
Age at menarche (years)
≤12 2.14(1.36–3.36) 1.59(1.09–2.30) 0.85(0.66–1.08) 0.85(0.60–1.22)
13–14 0.95(0.71–1.28) 1.44(1.18–1.75) 1.08(0.97–1.22) 0.93(0.79–1.10)
15 Ref. Ref. Ref. Ref.
16 0.74(0.56–0.97) 0.86(0.70–1.04) 0.96(0.87–1.07) 1.07(0.92–1.23)
≥17 0.96(0.76–1.21) 0.86(0.71–1.02) 1.01(0.92–1.11) 1.12(0.98–1.28)
Number of live births
≤1 Ref. Ref. Ref. Ref.
2 0.49(0.34–0.68) 0.64(0.49–0.84) 0.84(0.71–0.98) 1.95(1.48–2.58)
≥3 0.38(0.28–0.53) 0.54(0.43–0.69) 0.69(0.60–0.80) 1.63(1.25–2.13)
Age at first birth (years)
<20 Ref. Ref. Ref. Ref.
20–24 1.23(1.02–1.50) 1.07(0.93–1.23) 1.10(1.02–1.19) 0.96(0.87–1.07)
25–29 1.33(0.93–1.91) 1.01(0.77–1.33) 1.11(0.96–1.28) 0.75(0.60–0.94)
≥30 1.39(0.60–3.21) 0.42(0.16–1.07) 0.89(0.61–1.29) 0.83(0.48–1.45)

Bold values represent significant results.

Ref.: reference group, OR: odds ratio, CI: confidence interval.