Table 1. Virulence and antibiotic resistance encoding genes of the novel MRSA variants.
| CC | Novel MRSA variants (N) | Spa types (N) | Antibiogram | SCCmec-associated markers | Antibiotic resistance genes | Toxin genes | Miscellaneous |
| CC1 | CC1-MRSA-[V/VT+fusC] (PVL+) (8) | t127 (2), t2207 (6) | GM (2), K (6), E (5), CC (5), TE (5), FD (8) | ugpQ, mecA, fusC, “ccrAA”, ccrC | ermC, aacA-aphD, aphA3, cat, qacC | PVL; sea, sed, seh, sek, seq | agrIII; cap8; sak, scn; icaA/C/D |
| CC1-MRSA-[V/VT+fusC] (2) | t127 (2) | GM (1), K (1), TP (2), FD (2) | ugpQ, mecA, fusC, ccrC | aacA-aphD | sea, seb, seh, sek, seq | argIII; cap8; sak, scn; icaA/C/D | |
| CC1-MRSA-PseudoSCCmec [class B mec+fusC+ccrA1B1] (1) | t127 (1) | GM, K, FD | ugpQ, mecA, Delta mecR1, fusC, ccrA/B-1 | aacA-aphD | sea, seh, sek, seq | agrIII; cap8; sak, scn; icaA/C/D | |
| CC5 | CC5-MRSA-[V/VT+fusC] (PVL+) (1) | t1588 (1) | FD (1) | ugpQ, mecA, fusC, “ccrAA”, ccrC | fosB | PVL; sea, sec, sed, sej, sel, ser, *egc | agrII; cap5; sak, chp, scn; icaA/C/D |
| CC6 | CC6-MRSA-[IV+fusC+ccrC] (1) | t14700 (1) | C, FD | ugpQ, mecA, Delta mecR1, fusC, ccrA/B-2, ccrC, dcs | fosB | Sea | agrI; cap8; sak, scn; icaA/C/D |
| CC8 | CC8-MRSA-[V/VT+fusC] (6) | t008 (5), t211 (1) | FD (6), CIP (6) | ugpQ, mecA, fusC, “ccrAA”, ccrC | fosB | sea (N315), seb | agrI; cap5; sak, scn; icaA/C/D |
| CC22 | CC22-MRSA-IV [tst1+ / PVL+] (12) | t005 (7), t309 (3), t223 (1), t10659 (1) | GM (9), K (8), E (8), CC (8), TP (11), CIP (9) | ugpQ, mecA, Delta mecR1, ccrA/B-2, dcs | ermC, aacA-aphD, dfrS1 | PVL; tst1; sec, sel, egc | agrI; cap5; sak, chp, scn; icaA/C/D |
| CC22-MRSA-[VI+fusC] (1) | t16578 (1) | FD | ugpQ, mecA, Delta mecR1, fusC, ccrB-4 | tst1; egc | agrI; cap5; sak, chp, scn; icaA/C/D | ||
| CC | Novel MRSA variants (N) | Spa types (N) | Antibiogram | SCCmec-associated markers | Antibiotic resistance genes | Toxin genes | Miscellaneous |
| CC30 | CC30-MRSA-[VI+fusC] (PVL+) (12) | t018 (6), t012 (1), t021 (4), t318 (1) | K (2), E (3), CC (3), TE (4), TP (4), FD (11), CIP (1) | ugpQ, mecA, Delta mecR1, fusC, ccr(A)/B-4, dcs | ermC, linA, aadD, tetK, dfrS1, fosB | PVL; tst1; sea, egc | agrIII; cap8; sak, chp, scn; icaA/C/D |
| CC30-MRSA-[VI+fusC] (3) | t018 (1), t021 (1), t253 (1) | TE (1), TP (1), FD (2) | ugpQ, mecA, Delta mecR1, fusC, ccr(A)/B-4, dcs | aadD, tetK, fosB | tst1; sea, egc | agrIII; cap8; sak, chp, scn; icaA/C/D | |
| CC45 | CC45-MRSA-[VI+fusC] (2) | t362 (2) | FD (2) | ugpQ, mecA, Delta mecR1, fusC, ccrA/B-4, dcs | egc | agrI; cap8; sak, chp, scn; icaA/C/D | |
| CC88 | CC88-MRSA-[IV+fusC] (2) | t786 (1), t2622 (1) | TP (1), FD (2), TE (2) | ugpQ, mecA, Delta mecR1, fusC, ccrA/B-2, (dcs, ccrB4) | dfrS1, tetK | sea (N315) | agrIII, cap8; sak, chp, scn;icaA/C/D |
| CC97 | CC97-MRSA-[V/VT+fusC+ccrA2B2] (1) | t2297 (1) | FD | ugpQ, mecA, fusC, ccrA/B-2, “ccrAA”, ccrC | agrI; cap5; sak, scn; icaA/C/D | ||
| CC97-MRSA-[VI+fusC] (1) | t359 (1) | TP, FD | ugpQ, mecA, Delta mecR1, fusC, ccrA/B-4 | dfrS1 | agrI; cap5; sak, scn; icaA/C/D | ||
| CC121 | CC121-MRSA-[V/VT+fusC] (PVL+) (5) | t314 (4), t1991 (1) | GM (5), K (5), TE (4), FD (5), CIP (1) | ugpQ, mecA, fusC, “ccrAA”, ccrC | aacA-aphD, tetK, fosB | PVL; seb, egc | agrIV; cap8; sak, scn; icaA/C/D |
| CC121-MRSA-[V/VT+fusC+ccrB4] (PVL+) (1) | t314 (1) | FD | ugpQ, mecA, fusC, “ccrAA”, ccrC, ccrB-4 | fusC, fosB | PVL; seb, egc | agrIV; cap8; sak, scn; icaA/C/D | |
| CC152 | CC152-MRSA-[V+fusC] (PVL+) (5) | t355, t4019, t11206 | GM (4), K (4), TE (4), FD (5) | ugpQ, mecA, fusC, “ccrAA”, ccrC | aacA-aphD, tetK | PVL | agrI; cap5; sak/scn; icaA/D; edinB |
| CC | Novel MRSA variants (N) | Spa types (N) | Antibiogram | SCCmec-associated markers | Antibiotic resistance genes | Toxin genes | Miscellaneous |
| CC152 | CC152-MRSA-[VI+fusC] (PVL+) (1) | t4019 | TP, TE, FD | ugpQ, mecA, Delta mecR1, fusC, ccrB-4 | dfrS1, tetK | PVL | agrI; cap5; sak/scn; icaA/D; edinB |
| CC361 | CC361-MRSA-[V/VT+fusC] (32) | t3841 (28), t1309 (1), t15778 (1), t3175 (1), t16901 (1) | GM (4), K (18), E (16), CC (3), C (1), TP (30), TE (2), FD (28), CIP (30) | ugpQ, mecA, fusC, “ccrAA”, ccrC | msr(A), mphC, ermC, aphA3, sat, dfrS1, tetK, fosB, qacC | sed, egc | agrI; cap8; sak, scn; icaA/C/D |
| CC913 | CC913-MRSA-[VI+fusC] (3) | t991 (3) | E (3), CC (3), TP (3), FD (3) | ugpQ, mecA, Delta mecR1, fusC, ccrB-4, (dcs) | ermC, dfrS1, fusC | etA, etD | agrII; cap8; sak/chp/scn; icaA/C/D; edinB |
| CC1153 | CC1153-MRSA-[I+fusC] PVL+ (1) | t504 | FD | ugpQ, mecA, Delta mecR1, fusC, ccrA/B-1 | PVL | agrII; cap5; sak, scn; icaA/C/D | |
| Singleton | ST2867-MRSA-V/VT (1) | t148 | ugpQ, mecA, ccrC | fosB | agrII; cap5; sak/scn; icaA/C/D; edinB |
Abbreviations: C, Chloramphenicol; FD, fusidic acid; GM, gentamicin; CIP, ciprofloxacin; CC, clindamycin; E, erythromycin; K, kanamycin; TE, tetracycline; TP, trimethoprim.
*egc (seg, sei, selm, seln, selo, selu).
ND-not determined