. 2018 Apr 18;13(4):e0194267. doi: 10.1371/journal.pone.0194267

Table 2. Clinical parameters of the study population in the first 30 days of life.

Patient ID	CFM^a	EEG^a	MRI 1^a	MRI 2^a	CPK^a	Troponin^a	Pre-TH arterial lactate^a	Post-TH arterial lactate^a	Kidney function^a	Cardiac US^a	Follow-up
U001	1	1	1	1	2	0	2 (50)	1 (10)	1	0	Mild motor posture delay at 9 months
U003	0	1	0	0	1	na	2 (109)	2 (21)	0	0	Normal
U004	2	2	2	exitus	1	1	2 (112)	2 (18)	2	2	Deceased
U005	1	1	0	0	2	2	2 (130)	1 (13)	0	0	Normal
U006	1	1	1	1	na	na	2 (43)	1 (13)	1	0	Normal
U007	0	0	0	0	0	0	2 (58)	0 (6)	1	1	Normal
U008	0	1	1	0	1	2	2 (66)	1 (14)	1	0	Normal
U010	2	2	2	exitus	2	2	2 (154)	2 (41)	2	2	Deceased
U011	1	1	1	0	2	1	2 (36)	0 (5)	0	0	Normal
U012	1	2	2	exitus	2	2	2 (185)	2 (25)	2	2	Deceased

Abbreviations: CFM = Cerebral Function Monitoring; EEG = ElectroEncephaloGraphy; MRI = Magnetic Resonance Imaging; CPK = Creatine Phospho Kinase; US = UltraSound.

^aAn arbitrary classification scale was used to codify the clinical parameters

Code 0 = No alterations in CFM, EEG, MRI, Kidney function and Cardiac US; CPK ≤ 1000 (U/L); Troponin < 0,20 (ng/mL); Arterial lactate < 7 (meq/L).

Code 1 = Moderate alterations in CFM (convulsion or depressed), EEG (slow voltage, rhythm period, foc attacks, peak-wave complexes), MRI, Kidney function (temporary AKI) and Cardiac US; 1000 < CPK < 5000 (U/L); 0,20 < Troponin < 0,50 (ng/mL); 7 < Arterial lactate < 15 (meq/L).

Code 2 = Severe alterations in CFM (burst suppression), EEG (rhythm period with inactive phases), MRI, Kidney function (severe AKI) and Cardiac US; CPK > 5000 (U/L); Troponin > 0,50 (ng/mL); Arterial lactate > 15 (meq/L).