Table 3. Metabolomics data.
Major metabolic changes in the HIE population over time.
| HIE day 1 compared to Healthy day 1 | HIE day 3 compared to HIE day 1 | HIE day 30 compared to HIE day 1 | |||
|---|---|---|---|---|---|
| Increased | Decreased | Increased | Decreased | Increased | Decreased |
| Lactate | Citrate | Creatine/Creatinine | Myo-inositol | Citrate | Myo-inositol |
| Myo-inositol | Acetone | Citrate | Betaine | Betaine | Lactate |
| Betaine | DMA | DMG | MNA | DMA | Creatine/Creatinine |
| Taurine | Glutamine | DMA | Lactate | Glutamine | MNA |
| Succinate | cis-Aconitate | Choline/P-Choline | Pyruvate | Arginine | |
| Pyruvate | 3-aminoisobutyrate | Taurine | α-Ketoglutarate | Acetate | |
| α-Ketoglutarate | Galactose | Arginine | Galactose | Hypoxanthine | |
| N-Ac groups | Lactose | Hypoxanthine | Lactose | ||
| Acetate | Glutamine | Formate | |||
| Arginine | α -Ketoglutarate | Succinate | |||
| Glucose | N-Ac-Groups | ||||
| N-Ac groups | DMG | ||||
| Pyruvate | cis-Aconitate | ||||
DMA = dimethylamine; MNA = 1-Methyl-Nicotinammide; DMG = N,N-dimethylglycine