Table 3. Effect of BMI: Subgroup analysis by sex and age.

	BMI category (kg/m2)	Cases	Incidence rate (person-years)	Crude HR (95% CI)	P-value	aHR (95% CI)*	P-value
Male
Age <50 years	<18.5	50	13473.6	2.07 (1.48–2.9)	<.0001	1.77 (1.22–2.56)	0.0028
	18.5 to 22.9	400	222239.6	1 (Reference)		1 (Reference)
	23 to 24.9	172	171368.7	0.53 (0.43–0.65)	<.0001	0.53 (0.42–0.65)	<0.0001
	25 to 29.9	150	212613.6	0.37 (0.30–0.46)	<.0001	0.37 (0.29–0.47)	<0.0001
	≥ 30	9	23528.0	0.24 (0.12–0.49)	<.0001	0.17 (0.07–0.41)	<0.0001
Age ≥50 years	<18.5	92	9226.1	1.64 (1.27–2.10)	0.0001	1.44 (1.08–1.91)	0.0122
	18.5 to 22.9	672	130191.5	1 (Reference)		1 (Reference)
	23 to 24.9	326	112703.6	0.60 (0.52–0.70)	<.0001	0.60 (0.51–0.71)	<0.0001
	25 to 29.9	280	133441.0	0.46 (0.39–0.54)	<.0001	0.49 (0.42–0.58)	<0.0001
	≥ 30	11	8293.1	0.31 (0.16–0.60)	0.0005	0.33 (0.16–0.66)	0.0018
Female
Age <50 years	<18.5	59	41528.0	0.93 (0.68–1.29)	0.6774	0.93 (0.67–1.30)	0.6718
	18.5 to 22.9	381	258746.3	1 (Reference)		1 (Reference)
	23 to 24.9	69	78408.6	0.61 (0.46–0.82)	0.0009	0.59 (0.44–0.80)	0.0007
	25 to 29.9	49	61209.5	0.53 (0.38–0.75)	0.0003	0.52 (0.37–0.75)	0.0004
	≥ 30	10	8463.8	0.81 (0.40–1.63)	0.5494	0.77 (0.36–1.63)	0.4957
Age ≥50 years	<18.5	56	9418.0	1.53 (1.10–2.13)	0.0114	1.51 (1.07–2.13)	0.0185
	18.5 to 22.9	440	146344.5	1 (Reference)		1 (Reference)
	23 to 24.9	272	115370.2	0.80 (0.68–0.96)	0.0131	0.81 (0.68–0.97)	0.0203
	25 to 29.9	241	144520.0	0.52 (0.43–0.62)	<.0001	0.48 (0.40–0.58)	<0.0001
	≥ 30	33	18018.4	0.56 (0.37–0.85)	0.0066	0.59 (0.39–0.89)	0.0126

Abbreviations: BMI, body mass index.

*Adjusted by household income, smoking status, alcohol use, and diabetes