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. 2018 Apr 6;12(4):e0006376. doi: 10.1371/journal.pntd.0006376

Fig 3. Serum antibody responses against OSP in vaccinees of day 90 challenged group.

Fig 3

Serum IgM, IgA and IgG responses targeting V. cholerae O1 Inaba or Ogawa OSP in recipients (n = 20) of oral cholera vaccine CVD 103-HgR who were then experimentally challenged with wild type V. cholerae O1 Inaba N16961 90 days after vaccination (denoted by top arrows). Day 0 is pre-vaccination and other dates are timed from vaccination. X axis indicates the time points of samples, while Y-axis denotes OSP-specific antibody responses. Each single dot indicates an individual OSP antibody value, horizontal bars indicate the geometric mean (GM), and error bars indicate 95% confidence intervals. P values represent differences of the mean between groups. Asterisks represent significant differences of responder frequency in Fisher’s exact test (*** P ≤ 0.001, ** P ≤ 0.01). We defined a responder as having a ≥1.5-fold increase in anti-OSP units compared to pre-vaccination value. Responder frequency is represented in parenthesis on x-axis.