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. 2018 Apr 6;12(4):e0006376. doi: 10.1371/journal.pntd.0006376

Fig 4. Serum IgM, IgA and IgG antibody responses targeting V. cholerae O1 Inaba and Ogawa OSP 10 days after oral vaccination.

Fig 4

The figure shows the OSP specific antibodies responses 10 days after vaccination in volunteers who developed moderate (≥3L) or severe (≥5L) diarrhea versus no diarrhea following wild type V. cholerae O1 Inaba experimental infection 10 or 90 days after vaccination. X axis indicates the time points of samples while Y-axis denotes OSP specific antibody responses. Each single dot indicates an individual OSP antibody value, horizontal bars indicate the geometric mean (GM), and error bars indicate 95% confidence intervals. Responders were defined as having an increase in kinetic ELISA units ≥ 1.5 fold on day 10 post-vaccination compared with day 0 pre-vaccination. Asterisk indicates statistical significant difference (* P ≤ 0.05) of responder frequency between no diarrhea versus moderate/severe diarrhea group in Fisher’s exact test.