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Left with no radiation (No RT): Cellular proliferation was markedly reduced in the stable transfectants with anti-STAT-3 shRNA (2.1) compared to controls (parental and mutant shRNA transfectants Neg clone 4.1). Right with 3 Gy of Radiation: This decrease in proliferation (due to STAT-3 inhibition) did not enhance the radiation-induced anti-proliferative effect. Cellular proliferation was assessed as described in the Materials and Methods section. Means and standard errors are shown.
