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Intratumoral and intertumoral heterogeneity in somatic alterations. For each patient, a heatmap was generated that lists genes affected by somatic alterations (top panel), genes affected by copy number alterations (CNAs; middle panel), and genes involved in gene fusions (bottom panel). Note the absence of focal CNAs in CAP-004. From left to right: the status of the mutation across the cores of the index lesion (Td1) and the other lesions (Td2–5).
