Table 3.
SNP-breast cancer associations for SNPs in selected candidate genes (N=3,334; 1810 in sub-cohort [66 cases] and 1,524 additional cases)
| SNP-Breast Cancer association rank | Overall rank for GxE | SNP | Location | Gene | Hazard Ratio (95% CI) | p-value |
|---|---|---|---|---|---|---|
| 1 | 43 | rs2238135 | 12: 48278190 | VDR | 1.17 (1.04, 1.30) | 0.007 |
| 2 | 2 | rs11168287 | 12: 48285414 | VDR | 1.13 (1.03, 1.25) | 0.01 |
| 3 | 11 | rs1989969 | 12: 48278010 | VDR | 0.89 (0.81, 0.98) | 0.02 |
| 4 | 34 | rs2238136 | 12: 48277713 | VDR | 1.14 (1.02, 1.28) | 0.02 |
| 5 | 4 | rs4237855 | 12: 48287203 | VDR | 1.11 (1.01, 1.23) | 0.03 |
| 6 | 6 | rs4516035 | 12: 48299826 | VDR | 0.90 (0.82, 1.00) | 0.05 |
| 7 | 17 | rs2853564 | 12: 48278487 | VDR | 0.91 (0.83, 1.01) | 0.06 |
| 8 | 69 | rs7136534 | 12: 48294626 | VDR | 0.91 (0.81, 1.01) | 0.09 |
| 9 | 1 | rs4328262 | 12: 48285648 | VDR | 1.09 (0.98, 1.20) | 0.10 |
| 10 | 64 | rs2248461 | 20: 52792202 | CYP24A1 | 1.07 (0.97, 1.17) | 0.18 |
| 11 | 48 | rs2254210 | 12: 48273714 | VDR | 0.93 (0.85, 1.03) | 0.18 |
| 12 | 59 | rs2248359 | 20: 52791518 | CYP24A1 | 1.06 (0.97, 1.17) | 0.20 |
| 13 | 49 | rs1352844 | 4: 72647749 | GC | 1.09 (0.95, 1.25) | 0.22 |
| 14 | 47 | rs1045570 | 9: 137332311 | RXRA | 1.08 (0.95, 1.23) | 0.26 |
| 15 | 26 | rs11574143 | 12: 48234917 | VDR | 0.91 (0.78, 1.07) | 0.26 |
| 16 | 81 | rs78077736 | 9: 137257165 | RXRA | 1.13 (0.91, 1.40) | 0.27 |
| 17 | 5 | rs17883984 | 12: 48293716 | VDR | 0.94 (0.85, 1.05) | 0.28 |
| 18 | 25 | rs2181874 | 20: 52784478 | CYP24A1 | 1.06 (0.95, 1.18) | 0.29 |
| 19 | 29 | rs2296241 | 20: 52786219 | CYP24A1 | 0.95 (0.86, 1.05) | 0.29 |
| 20 | 62 | rs2239180 | 12: 48256046 | VDR | 0.92 (0.79, 1.08) | 0.31 |
| 21 | 61 | rs3733359 | 4: 72649774 | GC | 0.92 (0.78, 1.10) | 0.37 |
| 22 | 74 | rs9615 | 9: 137331525 | RXRA | 0.90 (0.70, 1.15) | 0.39 |
| 23 | 32 | rs757343 | 12: 48239675 | VDR | 0.94 (0.81, 1.09) | 0.42 |
| 24 | 28 | rs2248098 | 12: 48253356 | VDR | 1.04 (0.94, 1.14) | 0.44 |
| 25 | 46 | rs11168275 | 12: 48272275 | VDR | 1.04 (0.93, 1.17) | 0.45 |
| 26 | 30 | rs2762934 | 20: 52771261 | CYP24A1 | 1.04 (0.92, 1.18) | 0.50 |
| 27 | 67 | rs10877012 | 12: 58162085 | CYP27B1 | 1.04 (0.93, 1.15) | 0.51 |
| 28 | 19 | rs7967152 | 12: 48244184 | VDR | 1.03 (0.94, 1.13) | 0.53 |
| 29 | 18 | rs2228572 | 12: 48272840 | VDR | 0.91 (0.67, 1.24) | 0.55 |
| 30 | 76 | rs11168267 | 12: 48251542 | VDR | 0.95 (0.80, 1.13) | 0.56 |
| 31 | 21 | rs4917354 | 9: 137237661 | RXRA | 0.97 (0.88, 1.08) | 0.58 |
| 32 | 37 | rs10898193 | 11: 71197083 | NADSYN1 | 0.97 (0.85, 1.09) | 0.59 |
| 33 | 40 | rs35603635 | 9: 137323202 | RXRA | 0.93 (0.71, 1.21) | 0.59 |
| 34 | 44 | rs61749689 | 20: 52790005 | CYP24A1 | 0.92 (0.66, 1.26) | 0.60 |
| 35 | 65 | rs222009 | 4: 72631735 | GC | 1.11 (0.76, 1.62) | 0.60 |
| 36 | 71 | rs11574026 | 12: 48288246 | VDR | 0.96 (0.82, 1.12) | 0.61 |
| 37 | 7 | rs2239182 | 12: 48255411 | VDR | 0.98 (0.89, 1.07) | 0.61 |
| 38 | 3 | rs117913124 | 11: 14900931 | CYP2R1 | 0.92 (0.67, 1.27) | 0.62 |
| 39 | 66 | rs4364228 | 4: 72623347 | GC | 1.04 (0.89, 1.22) | 0.63 |
| 40 | 10 | rs3118536 | 9: 137308462 | RXRA | 1.03 (0.91, 1.17) | 0.64 |
| 41 | 50 | rs12717991 | 12: 48259126 | VDR | 0.98 (0.89, 1.08) | 0.66 |
| 42 | 31 | rs9729 | 12: 48236623 | VDR | 1.02 (0.93, 1.12) | 0.68 |
| 43 | 57 | rs1540339 | 12: 48257326 | VDR | 0.98 (0.89, 1.09) | 0.72 |
| 44 | 60 | rs7038018 | 9: 137309959 | RXRA | 0.98 (0.85, 1.12) | 0.72 |
| 45 | 8 | rs3132301 | 9: 137294030 | RXRA | 0.98 (0.87, 1.11) | 0.74 |
| 46 | 9 | rs3132296 | 9: 137302631 | RXRA | 0.98 (0.89, 1.09) | 0.74 |
| 47 | 45 | rs1570669 | 20: 52774427 | CYP24A1 | 0.98 (0.89, 1.09) | 0.75 |
| 48 | 78 | rs6022987 | 20: 52770596 | CYP24A1 | 1.02 (0.92, 1.12) | 0.75 |
| 49 | 77 | rs3782905 | 12: 48266167 | VDR | 1.02 (0.92, 1.13) | 0.76 |
| 50 | 20 | rs2239179 | 12: 48257766 | VDR | 1.01 (0.92, 1.12) | 0.77 |
| 51 | 13 | rs11102986 | 9: 137285503 | RXRA | 0.98 (0.87, 1.11) | 0.78 |
| 52 | 14 | rs7129781 | 11: 14912417 | CYP2R1 | 1.02 (0.86, 1.21) | 0.80 |
| 53 | 80 | rs927650 | 20: 52772741 | CYP24A1 | 0.99 (0.90, 1.08) | 0.80 |
| 54 | 53 | rs705120 | 4: 72614140 | GC | 1.01 (0.92, 1.11) | 0.80 |
| 55 | 22 | rs1155563 | 4: 72643488 | GC | 0.99 (0.89, 1.10) | 0.80 |
| 56 | 68 | rs2283342 | 12: 48255859 | VDR | 0.98 (0.86, 1.13) | 0.81 |
| 57 | 27 | rs2239186 | 12: 48269410 | VDR | 1.02 (0.90, 1.15) | 0.81 |
| 58 | 16 | rs886441 | 12: 48262964 | VDR | 1.01 (0.90, 1.14) | 0.83 |
| 59 | 38 | rs1044535 | 11: 71145778 | DHCR7 | 0.98 (0.83, 1.17) | 0.84 |
| 60 | 33 | rs2228570 | 12: 48272895 | VDR | 0.99 (0.90, 1.09) | 0.85 |
| 61 | 35 | rs16999116 | 20: 52777467 | CYP24A1 | 0.99 (0.86, 1.13) | 0.87 |
| 62 | 63 | rs143304420 | 11: 71144815 | DHCR7 | 0.98 (0.74, 1.29) | 0.87 |
| 63 | 72 | rs34312136 | 9: 137269456 | RXRA | 1.01 (0.91, 1.11) | 0.87 |
| 64 | 73 | rs10741657 | 11: 14914878 | CYP2R1 | 0.99 (0.90, 1.09) | 0.88 |
| 65 | 36 | rs35873579 | 20: 52788190 | CYP24A1 | 0.98 (0.72, 1.32) | 0.88 |
| 66 | 54 | rs12785878 | 11: 71167449 | NADSYN1 | 1.01 (0.91, 1.12) | 0.89 |
| 67 | 70 | rs11907350 | 20: 52770439 | CYP24A1 | 0.98 (0.77, 1.26) | 0.89 |
| 68 | 79 | rs10875693 | 12: 48269650 | VDR | 1.01 (0.91, 1.12) | 0.89 |
| 69 | 42 | rs3819545 | 12: 48265006 | VDR | 0.99 (0.90, 1.10) | 0.90 |
| 70 | 58 | rs67816242 | 9: 137268441 | RXRA | 1.01 (0.90, 1.13) | 0.90 |
| 71 | 55 | rs6537998 | 9: 137292505 | RXRA | 1.02 (0.74, 1.40) | 0.90 |
| 72 | 41 | rs7975128 | 12: 48245828 | VDR | 0.99 (0.90, 1.10) | 0.90 |
| 73 | 56 | rs222020 | 4: 72636272 | GC | 0.99 (0.88, 1.12) | 0.91 |
| 74 | 15 | rs12794714 | 11: 14913575 | CYP2R1 | 0.99 (0.90, 1.09) | 0.91 |
| 75 | 75 | rs2296239 | 20: 52775528 | CYP24A1 | 1.01 (0.90, 1.12) | 0.92 |
| 76 | 23 | rs1805343 | 9: 137328286 | RXRA | 1.00 (0.90, 1.10) | 0.94 |
| 77 | 12 | rs35079168 | 9: 137280939 | RXRA | 1.00 (0.91, 1.11) | 0.94 |
| 78 | 52 | rs11185660 | 9: 137259992 | RXRA | 1.00 (0.90, 1.12) | 0.95 |
| 79 | 24 | rs4588 | 4: 72618323 | GC | 1.00 (0.90, 1.11) | 0.97 |
| 80 | 39 | rs4809958 | 20: 52782438 | CYP24A1 | 1.00 (0.88, 1.14) | 0.97 |
| 81 | 51 | rs731236 | 12: 48238757 | VDR | 1.00 (0.91, 1.10) | 0.97 |
| 82 | 82 | rs2107301 | 12: 48255570 | VDR | 1.00 (0.90, 1.11) | 0.99 |