Table 4.
Gene-environment set association tests (GESAT) for 25(OH)D and vitamin D-related genes on the 5-year risk of breast cancer (N=3,334; 1,590 cases, 1,744 controls/non-cases)
| Gene | Number of included SNPs | GESAT p-value |
|---|---|---|
| VDR | 35 | 0.04 |
| RXRA | 16 | 0.19 |
| CYP2R1 | 4 | 0.22 |
| GC | 8 | 0.38 |
| DHCR7/NADSYN1 | 4 | 0.53 |
| CYP24A1 | 14 | 0.65 |
Gene-level effects were not calculated for CYP27B1 (1 SNP).