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. Author manuscript; available in PMC: 2018 Apr 18.
Published in final edited form as: Exp Gerontol. 2016 Dec 7;88:1–8. doi: 10.1016/j.exger.2016.12.003

Figure 4. Effect of MR on gene-specific methylation in liver.

Figure 4

Young (8-week-old) and adult (1-year-old) male C57BL/6J mice were fed ad libitum with diets containing either 0.12% methionine (MR) or 0.84% methionine (CD) for 12 weeks. Changes induced by MR in GSM of liver in adult (panel b) and young mice (panel c) are opposite to those changes occurred during aging on CD (panel a). Note: CpG sites with at least a 2-fold difference by 2-way ANOVA are presented (p<0.05). CpG sites on x-axis are ranked based on the natural levels of methylation in young mice on CD (methylation levels are indicated at the bottom of vertical lines). A positive value indicates higher methylation in adult mice (panel a) and mice on MR (panels b and c). Bars represent average (n=4/group) difference in percent methylation at each CpG site.