Table 2.

Comparison of cocaine (15 mg/kg i.p.) induced changes in striatal neurochemistry between bHRs and bLRs across all time points (−60 to 60 min) using a two-way RM ANOVA. Only dopamine, norepinephrine, 3MT and glycine showed time × cocaine treatment interactions. Specific time points where bHRs and bLRs differed were shown by a Bonferroni post hoc test and are shown in the right most column.

Neurochemical in NAc	FTime	FPhenotype	FTime × Phenotype	PTime	PPhenotype	PTime × Phenotype	sig.	Post hoc (min)
Dopamine	18.28	11.64	5.05	<0.0001	0.01	<0.0001	***	15-30, 45
Norepinephrine	19.93	2.46	1.82	<0.0001	0.15	0.015	**	25-30
Serotonin	19.89	0.01	0.64	<0.0001	0.96	0.90	–	–
DOPAC	2.83	0.69	0.51	<0.0001	0.43	0.96	–	–
HVA	0.94	0.22	0.59	0.55	0.65	0.93	–	–
3-MT	23.42	3.73	2.35	<0.0001	0.08	0.0007	**	15-20, 30
Normetanephrine	9.91	1.07	1.54	<0.0001	0.33	0.06	–	–
5-HIAA	1.50	0.10	0.44	0.07	0.75	0.99	–	–
Histamine	7.40	0.99	1.19	<0.0001	0.34	0.26	–	–
ACh	1.50	1.46	1.18	0.07	0.25	0.27	–	–
Glutamate	3.37	0.58	1.32	<0.0001	0.47	0.16	–	–
GABA	2.26	0.33	1.05	0.0013	0.58	0.40	–	–
Adenosine	1.33	1.59	0.77	0.15	0.24	0.77	–	–
Taurine	3.04	0.96	0.82	<0.0001	0.35	0.71	–	–
Glycine	2.25	2.09	1.86	0.0013	0.18	0.012	*	10-15
Aspartate	1.95	0.02	1.21	0.0072	0.88	0.24	–	–
Serine	1.46	2.07	1.58	0.085	0.18	0.051	–	–

Significance (sig.) indicated by

^*p<0.05,

^**p<0.01,

^***p<0.001.