Table 3.
Clinical characteristics of patients with ALF who received or did not receive red blood cell transfusion during days 1–7.
| Clinical Feature | N | No RBC Transfusions N = 1119 (Mean N, %) |
RBC Transfusions N = 651 (Mean N, %) |
P |
|---|---|---|---|---|
| Demographics | ||||
| Age (Years) | 1770 | 42±15 | 41±14 | 0.15 |
| Gender (% Female) | 1770 | 744(66.5) | 477(73.3) | 0.003 |
| Race (Caucasian) | 1770 | 842(75.2) | 467(71.7) | 0.117 |
| APAP Etiology of ALF | 1770 | 523(46.7) | 275(42.2) | 0.075 |
| Clinical Features on Admission | ||||
| SIRS (% ≥ 2 ) | 1364 | 580(72.0) | 444(79.4) | 0.002 |
| Ammonia (μM) | 1032 | 98.0±90.0 | 101.0±97.0 | 0.826 |
| Encephalopathy Grade (% 3/4) | 1721 | 451(41.9) | 397(61.6) | < 0.001 |
| Creatinine (mg/dl) | 1766 | 1.3±1.9 | 2.1±2.3 | <0.001 |
| INR | 1770 | 2.9±2.2 | 2.8±2.2 | 0.129 |
| Total bilirubin (mg/dl) | 1752 | 7.0±15.6 | 8.0±17.0 | <0.001 |
| Albumin (g/dl) | 1616 | 2.7±0.7 | 2.7±0.8 | 0.17 |
| Lactate (mg/dl) | 971 | 3.9±4.7 | 5.9±7.7 | <0.001 |
| Bicarbonate (mg/dl) | 1481 | 22.0±8.0 | 20.0±8.8 | <0.001 |
| Phosphate (mg/dl) | 1539 | 3.0±2.2 | 3.4±2.7 | <0.001 |
| Platelet count (×109/L) | 1770 | 133.0±104.0 | 108.0±102.5 | <0.001 |
| WBC (×109/L) | 1770 | 9.6±7.4 | 10.9±9.9 | <0.001 |
| Hemoglobin (g/dl) | 1764 | 11.5±2.9 | 9.9±2.9 | <0.001 |
| Clinical Features after Admission, Days 1–7 | ||||
| INR peak | 1770 | 3.3±2.7 | 3.3±2.8 | 0.586 |
| Platelet count nadir (×109/L) | 1770 | 94.0±81.0 | 50.0±48.0 | <0.001 |
| Hemoglobin nadir (g/dl) | 1770 | 9.8±2.5 | 8.2±1.6 | <0.001 |
| Encephalopathy Grade ¾ | 1734 | 613(56.3) | 529(82.0) | < 0.001 |
| Infection | 1770 | 125(11.2) | 46(7.1) | 0.006 |
| Bleeding Complication | 1770 | 67(6.0) | 120(18.4) | < 0.001 |
| Interventions after Admission, Days 1–7 | ||||
| ICP Monitor Placement | 1634 | 99(9.4) | 138(23.7) | < 0.001 |
| Renal Replacement Therapy | 1770 | 271(24.2) | 370(56.8) | < 0.001 |
| Vasopressors | 1770 | 300(26.8) | 352(54.1) | < 0.001 |
| N-acetylcysteine | 1770 | 722(64.5) | 366(56.2) | < 0.001 |
| Gastric Acid Suppression | 1770 | 892(79.7) | 537(82.5) | 0.172 |
| Plasma Transfusion | 1770 | 210(18.8) | 85(13.1) | 0.002 |
| Platelet Transfusion | 1770 | 451(40.3) | 543(83.4) | < 0.001 |