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. Author manuscript; available in PMC: 2018 Apr 19.
Published in final edited form as: ACS Chem Neurosci. 2018 Jan 4;9(4):809–816. doi: 10.1021/acschemneuro.7b00434

Figure 3.

Figure 3

IN insulin substantially improves the brain:plasma ratio relative to SC insulin. Brain to plasma ratios of (left) Cmax and (right) AUC values obtained after subcutaneous (SC) and intranasal (IN) insulin (2.4 IU) administration were calculated. IN administration resulted in a greater than 200- and 2000-fold increases in the brain:plasma insulin Cmax and AUC ratios, respectively. Values depict the mean + SEM or mean; n = 3–8/group.