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A, ML375 (30 mg/kg, open squares) reduces breakpoints of the lower doses of cocaine compared to vehicle (black squares) sessions, n=7. This effect is not seen 24 hr post ML375 ( 30 mg/kg) injection (gray squares). B, ML375 does not reduce breakpoints for sugar pellets compared to vehicle at either 10 or 30 mg/kg, n=10. *, p < 0.05.
