Table 1. Demographic and disease characteristics of 100 patients with esophageal squamous cell carcinoma who received chemoradiotherapy followed by salvage esophagectomy.
| Characteristics | Total (n=100) | Residual (n=52) | Recurrent (n=48) | P value |
|---|---|---|---|---|
| Age (median/range) | 65/41–82 | 64/41–76 | 67/44–82 | 0.132 |
| Gender (male/female) | 0.781 | |||
| Male | 85 | 45 | 40 | |
| Female | 15 | 7 | 8 | |
| Pre-existing comorbidity | ||||
| Hypertension | 31 | 18 | 13 | 0.306 |
| Diabetes mellitus | 13 | 7 | 6 | 0.770 |
| Heavy smoking habit* | 54 | 29 | 25 | 0.477 |
| Radiation dose (Gy), (mean/median) | 61.4/60.0 | 61.6/60.0 | 61.2/60.0 | 0.361 |
| Period from CRT to surgery (days) (mean/median) | 268.0/190.5 | 145.0/115.0 | 401.0/265.5 | 0.001 |
| Before CRT | ||||
| T status | 0.001 | |||
| cT1 | 25 | 3 | 22 | |
| cT2 | 11 | 6 | 5 | |
| cT3 | 56 | 39 | 17 | |
| cT4 | 8 | 4 | 4 | |
| N status | 0.535 | |||
| cN(−) | 36 | 17 | 19 | |
| cN(+) | 64 | 35 | 29 | |
| Pathological | ||||
| T status | 0.001 | |||
| pT0 | 8 | 4 | 4 | |
| pT1 | 23 | 4 | 19 | |
| pT2 | 16 | 7 | 9 | |
| pT3 | 36 | 24 | 12 | |
| pT4 suspected | 17 | 13 | 4 | |
| N status | 0.153 | |||
| pN0 | 66 | 30 | 36 | |
| pN1 | 23 | 14 | 9 | |
| pN2 | 11 | 8 | 3 | |
| Tumor location | 0.619 | |||
| Upper | 17 | 8 | 9 | |
| Middle | 53 | 30 | 23 | |
| Lower | 30 | 14 | 16 | |
| Type of surgery | 1.000 | |||
| Thoracoscopic | 95 | 49 | 46 | |
| Open thoracic | 5 | 3 | 2 | |
| Curative resection | 0.057 | |||
| Curative | 82 | 39 | 43 | |
| Non-curative** | 18 | 13 | 5 |
*, Brinkmann index over 500; **, vertical margin pathologically positive. CRT, chemoradiotherapy.