Drug-induced nephrotoxicity is one of the leading causes of acute kidney injury worldwide. Nephrotoxicity of ciprofloxacin is often underestimated.

In addition to causing acute kidney injury, chronic drug toxicity can in some cases lead to chronic kidney disease and eventually end-stage renal disease. Thus, the prevention of ciprofloxacin nephrotoxicity should be at the forefront of the approaches employed to counteract drug-induced kidney failure.

We have specifically highlighted ciprofloxacin overdose through our cases, with an updated review of the literature.