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. 2018 Apr 18;8:6215. doi: 10.1038/s41598-018-24542-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Metabolic profiling of selected DGRP fly lines. (A) Experimental outline of the profiling experiment. In order to minimize environmental effects, we kept the population density constant for two generations. The subsequent offspring was metabolically profiled. Additionally, samples were collected for the gut microbiome sequencing experiments. (B) The investigated fly lines showed differences in the developmental timing. While the majority of fly lines showed the expected developmental timing, several lines showed differences in either the larval or pupal development. The adult flies hatched almost all at the same time. Late third instar larvae, female and male flies were collected and triacylglycerol (TAG), total protein, free glycerol, lactate, glycogen and glucose were measured. In order to identify linked metabolites, we performed correlation analyses for larvae (C), females (D) and males (E). Profiling experiment following scheme presented in (A) performed once. Asterisks in (C–E) indicate statistical significance levels with: *p < 0.05, **p < 0.01 and ***p < 0.001 based on t-test statistics.