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. 2018 Apr 18;9:1540. doi: 10.1038/s41467-018-03995-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Synaptic and membrane determinants of precisely timed _uEPSP-evoked action potentials. a Population average _uEPSPs during UPstate (black trace shows PYR to PYR neuron = 35 connections, orange trace shows PYR to SST neuron = 7 connections, green trace shows PYR to PV neuron = 14 connections). V_m marks show PYR-PYR: −51.7 mV, PYR-SST: −50.5 mV, PYR-PV: −45.7 mV. b The amplitude of mean _uEPSP is larger in PV neurons than in PYR or SST neurons. Open circles represent single connection, purple circle shows connection in an awake mouse, filled circle with error bars shows mean ± s.e.m. c The synaptic gain of PV neurons is positively correlated with the mean _uEPSP amplitude, open circles represent a single connection, purple shows awake data, statistical values were taken from a linear correlation between Ln(synaptic gain) and _uEPSP amplitude. d Example V_m traces shows larger amplitude and more depolarized UPstate in a PV neuron (green, APs truncated) than in a PYR neuron (black) or a SST neuron (orange). e The mean _uEPSP V_m peak is significantly more depolarized in PV neurons than in SST or PYR neurons. f PV neuron synaptic gain is correlated with the difference between AP threshold (AP Thr.) and the _uEPSP V_m peak of the postsynaptic response in a 5-ms window after the presynaptic AP, the linear correlation was performed between Ln(synaptic gain) and (AP Thr.- _uEPSP V_m peak)