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. 2018 Apr 12;9:627. doi: 10.3389/fimmu.2018.00627

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Copyright © 2018 Martínez-Florensa, Català, Velasco-de Andrés, Cañadas, Fraile-Ágreda, Casadó-Llombart, Armiger-Borràs, Consuegra-Fernández, Casals and Lozano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparative therapeutic effects of intravenous (i.v.) infused CD6-derived peptides on mouse survival following cecal ligation and puncture (CLP)-induced sepsis. C57BL/6J mice were i.v. infused with saline (n = 31) or single 6 mg/kg doses of unlabeled CD6 (PD1, n = 8; PD2, n = 16; PD3, n = 22) or DMBT-1/SAG (pbs1, n = 13) derived peptides 1 h post CLP induction. A sham group (n = 3) was included, which received saline. The average percent survival was analyzed over time for each group and compared to the saline-treated group using the long-rank t-test (**P < 0.01; ***P < 0.001, ****P < 0.0001).