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. 2018 Apr 12;9:627. doi: 10.3389/fimmu.2018.00627

Figure 6.

Figure 6

Analysis of dose-, time-, and via-dependent effects of CD6.PD3 infusion on mouse survival following cecal ligation and puncture (CLP)-induced sepsis. (A) C57BL/6 mice were intravenous (i.v.) infused 1 h post CLP with saline (n = 26) or single increasing doses (3 mg/kg, n = 13; 6 mg/kg, n = 15; and 12 mg/kg, n = 8) of unlabeled CD6.PD3 peptide. (B) C57BL/6 mice were i.v. infused with saline (n = 5) or 6 mg/kg CD6.PD3 at different times post CLP (+1 h, n = 5; +3 h, n = 5; and +6 h, n = 6). (C) C57BL/6J mice were i.v. (n = 11) or intraperitoneally (n = 9) infused with 6 mg/kg CD6.PD3 peptide or saline (n = 9) 1 h post CLP. In all cases, average percentage of survival was analyzed over time and compared with the saline-treated group using a log-rank t-test (n.s., not significant; *P < 0.05. **P < 0.01; and ***P < 0.001).