Table 3.
Individual profiles of biomarker expressions between pre- and post-season (dark shade, drastic increase possibly due to brain trauma; gray shade, increase not related to brain trauma).
| Concussion | [CD81]SNAP25+ | [NF-L]SNAP25+/[CD81]SNAP25+ | [Tau]SNAP25+/[CD81]SNAP25+ | [TNFα]SNAP25+/[CD81]SNAP25+ | [IL8]SNAP25+/[CD81]SNAP25+ | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Previous | This season | Pre | Post | Fold | Pre | Post | Fold | Pre | Post | Fold | Pre | Post | Fold | Pre | Post | Fold |
| 1 | 4 | 0 | 2.38 | 1.75 | 0.73 | 6.85 | 45.4 | 6.63 | 1.77 | 6.01 | 3.39 | 4.89 | 33.1 | 6.76 | 6.10 | 58.2 | 9.54 |
| 2 | 0 | 0 | 0.24 | 0.61 | 2.51 | 6.21 | 15.5 | 2.49 | 2.36 | 3.63 | 1.54 | 9.66 | 12.8 | 1.33 | 10.7 | 17.1 | 1.60 |
| 3 | 2 | 1 | 23.2 | 13.4 | 0.58 | 2.86 | 6.40 | 2.24 | 2.15 | 2.43 | 1.13 | 2.30 | 3.92 | 1.71 | 2.42 | 4.76 | 1.97 |
| 4 | 1 | 0 | 0.54 | 0.62 | 1.16 | 10.8 | 27.6 | 2.56 | 2.49 | 7.60 | 3.05 | 9.30 | 22.2 | 2.38 | 12.0 | 31.3 | 2.61 |
| 5 | 0 | 0 | 0.06 | 0.15 | 2.74 | 39.3 | 43.8 | 1.12 | 7.90 | 9.88 | 1.25 | 36.0 | 33.4 | 0.93 | 43.9 | 45.4 | 1.03 |
| 6 | 1 | 1 | 2.31 | 1.05 | 0.46 | 14.6 | 14.1 | 0.96 | 4.50 | 2.21 | 0.49 | 9.85 | 10.0 | 1.02 | 14.6 | 13.9 | 0.95 |
| 7 | 2 | 0 | 4.28 | 6.29 | 1.47 | 3.38 | 3.48 | 1.03 | 1.74 | 1.99 | 1.14 | 2.58 | 2.68 | 1.04 | 2.52 | 3.04 | 1.21 |
| 8 | 0 | 0 | 2.16 | 1.86 | 0.86 | 16.7 | 16.9 | 1.01 | 3.08 | 3.09 | 1.00 | 11.5 | 12.3 | 1.07 | 17.2 | 15.5 | 0.90 |
| Concussion | [CD81]EAAT1+ | [GFAP]EAAT1+/[CD81]EAAT1+ | [CD81]OMG+ | [MBP]OMG+/[CD81]OMG+ | [SYP]CD11b+/[CD81]CD11b+ | ||||||||||||
| n | Previous | This season | Pre | Post | Fold | Pre | Post | Fold | Pre | Post | Fold | Pre | Post | Fold | Pre | Post | Fold |
| 1 | 4 | 0 | 1.83 | 1.16 | 0.63 | 2.42 | 4.79 | 1.98 | 2.78 | 1.81 | 0.65 | 8.29 | 88.9 | 10.73 | 36.3 | 48.5 | 1.34 |
| 2 | 0 | 0 | 0.21 | 0.68 | 3.28 | 4.34 | 3.20 | 0.74 | 0.46 | 1.42 | 3.06 | 14.0 | 10.5 | 0.75 | 8.48 | 18.5 | 2.19 |
| 3 | 2 | 1 | 27.2 | 16.2 | 0.60 | 0.85 | 1.26 | 1.49 | 32.3 | 19.5 | 0.60 | 5.08 | 10.3 | 2.02 | 77.7 | 156 | 2.01 |
| 4 | 1 | 0 | 0.81 | 1.02 | 1.25 | 2.64 | 4.88 | 1.85 | 1.42 | 1.73 | 1.22 | 8.76 | 16.0 | 1.82 | 16.6 | 30.0 | 1.80 |
| 5 | 0 | 0 | 0.03 | 0.14 | 4.11 | 29.0 | 14.5 | 0.50 | 0.07 | 0.27 | 4.16 | 66.0 | 34.9 | 0.53 | 6.20 | 10.3 | 1.66 |
| 6 | 1 | 1 | 2.72 | 0.60 | 0.22 | 3.90 | 4.67 | 1.20 | 4.83 | 0.69 | 0.14 | 13.2 | 32.9 | 2.50 | 89.5 | 31.6 | 0.35 |
| 7 | 2 | 0 | 17.1 | 34.6 | 2.02 | 0.41 | 0.26 | 0.64 | 19.8 | 37.3 | 1.88 | 1.67 | 1.33 | 0.80 | 28.4 | 20.4 | 0.72 |
| 8 | 0 | 0 | 2.61 | 2.53 | 0.97 | 3.64 | 3.11 | 0.86 | 5.20 | 4.67 | 0.90 | 7.88 | 9.16 | 1.16 | 60.0 | 50.2 | 0.84 |
Unit in units per millilitre for [CD81]SNAP25+, [CD81]EAAT1+, and [CD81]OMG+. Unit for rest of the biomarkers are in ratio. Unit in ratio.
SNAP25, synaptosome-associated protein 25, NF-L, neurofilament light polypeptide; TNFα, tumor necrosis factor-alpha; IL8, interleukin-8; EAAT1, excitatory amino acid transporter 1; GFAP, glial fibrillary acidic protein; OMG, oligodendrocyte myelin glycoprotein; MBP, myelin basic protein; SYP, synaptophysin.