Figure 1.

Number of distinct human endogenous retrovirus (HERV) elements per HERV family modulated by vorinostat treatment. HERV elements significantly differentially expressed (false discovery rate-corrected p-value < 0.05) with a log₂ fold change of greater than 3 or less than −3 between vorinostat treated and untreated samples are depicted. HERV elements were grouped into HERV families according to designations in the Human Endogenous Retrovirus Database. White bars represent the number of HERV elements upregulated by vorinostat and black bars the number of downregulated elements. For example, there were 140 distinct HERV elements belonging to the LTR12 family which were significantly upregulated with a log₂ fold change greater than 3 by vorinostat treatment.