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. 2018 Apr 12;9:603. doi: 10.3389/fimmu.2018.00603

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Copyright © 2018 White, Beliakova-Bethell, Lada, Breen, Hurst, Spina, Richman, Frater, Magiorkinis and Woelk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LTR12 elements are upregulated by vorinostat in a dose responsive manner. LTR12 expression was measured by droplet digital PCR using log₂ fold changes between each dose of vorinostat (0.34, 0.1, 0.3, and 10 μM) and the untreated control as calculated for (A) Donor 5 and (B) Donor 6. The labels “Set 1” and “Set 2” indicate the two distinct primer and probe sets used to target the same LTR12 element (i.e., rv_007357). LTR12 elements are labeled with their “rv” designation according to the Human Endogenous Retrovirus Database.