Table 2.

The characteristics of 19 monoclonal CXI antibodies.

Clones	Isotype	bCXI	rCXI	rCII	Bind cartilage
L3C11	IgG1	+	+	+	P
L5F3	IgG2b	++	++	+	P
L10D5	IgG2b	++	++	+	P
L10D9	IgG2a	+++	+++	++++	P
L13G8	IgG2b	++	++	+	P
L1D7	IgG2b	++	−	−	N
L1D8	IgG2b	++	++	−	N
L2D9	IgG2a, 2b	+	−	−	N
L2G11	IgG2b	−	+	−	N
L3E2	IgG2b	+	+	−	N
L7A2	IgG2b	+	+	−	N
L7B6	IgG1	++	++	+	N
L7D8	IgG2a	++	++	+	N
L7H5	IgG2b	+++	+	−	N
L8F2	IgG1	++	++	+	N
L10B9	IgG2a	+++	−	−	N
L11C5	IgG1	+++	+++	+	N
L14E2	IgG1	+	+	−	N
L16G4	IgG1	+++	−	+	N

Scale for optical density (OD) values: − denotes <3 times SEM of negative control; + denotes >mean + 3SD of negative control; ++ denotes >0.5 OD; +++ denotes >1.0 OD; ++++ denotes >1.5 OD. P, positive binding to the cartilage; N, negative binding to the cartilage; rCXI, rat CXI.