Figure 11.

Summary of anatomical results. Blue arrows indicate increased number of neurons retrogradely labeled with FB, and the brown arrow indicates increased axons anterogradely labeled with BDA. The ipsiCST was strengthened in rats with neonatal pyramidotomy. FB-labeled neurons were significantly increased in the ipsilateral (Ipsi) hemisphere when FB was injected into the impaired side of the spinal cord, and BDA-labeled axons were significantly increased in the impaired side of the spinal cord when BDA was injected into the ipsilateral hemisphere. In contrast, there were no differences in the corticoRST circuits from the injured hemisphere. The number of the FB-labeled neurons or the BDA-labeled axons in the red nucleus on the injured side was unchanged. There was an increase of retrogradely labeled neurons in the red nucleus in the uninjured hemisphere from the impaired side of the spinal cord. This is not part of the hypothesized corticoRST recovery circuit.